Introduction to Journal of Cell Science,Education of Journal of Cell Science

Education of journal of cell science

Vidal-Puig studied medicine and trained in endocrinology at University of Valencia Medical School and University of Granada Medical School. He held post-doctoral positions in Boston at the Massachusetts General Hospital and Beth Israel Hospital, Harvard Medical School, from 19921999., where his mentors included Jeff Flier, Brad Lowell, David Moller, and Leo Krall. In 2015 he completed the Executive Master of Business Administration at the Cambridge Judge Business School.

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Autogamy of journal of cell science

Autogamy, or self-fertilization, refers to the fusion of two gametes that come from one individual. Autogamy is predominantly observed in the form of self-pollination, a reproductive mechanism employed by many flowering plants. However, species of protists have also been observed using autogamy as a means of reproduction. Flowering plants engage in autogamy regularly, while the protists that engage in autogamy only do so in stressful environments

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Jean Lindenmann of journal of cell science

Jean Lindenmann (September 18, 1924 January 15, 2015) was a Swiss virologist and immunologist. Lindenmann, together with his colleague, the British virologist Alick Isaacs, co-discovered and identified interferon in 1957 through their research at the National Institute for Medical Research. Interferon, a group of proteins involved in immune regulation and defence against viruses, is now used to treat a variety of conditions, including hepatitis C, multiple sclerosis, and some cancers.

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Carl Neuberg of journal of cell science

Carl Alexander Neuberg (29 July 1877 30 May 1956) was an early pioneer in biochemistry, and he is often referred to as the "father of modern biochemistry". His notable contribution to science includes the discovery of the carboxylase and the elucidation of alcoholic fermentation which he showed to be a process of successive enzymatic steps, an understanding that became crucial as to how metabolic pathways would be investigated by later researchers

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DicF RNA of journal of cell science

DicF RNA is a non-coding RNA that is an antisense inhibitor of cell division gene ftsZ. DicF is bound by the Hfq protein which enhances its interaction with its targets. Pathogenic E. coli strains possess multiple copies of sRNA DicF in their genomes, while non-pathogenic strains do not. DicF and Hfq are both necessary to reduce FtsZ protein levels, leading to cell filamentation under anaerobic conditions.

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Pharmacodynamics of journal of cell science

Research of the effects on abnormal cannabidiol in mice has indicated that atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions, including those of the gastrointestinal tract. After inducing colitis by means of trinitrobenzene sulfonic acid, wound healing of both human umbilical vein endothelial and epithelial cells was enhanced by the Abn-CBD.

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Selected research citations of journal of cell science

"An embryonic chick pancreas organ culture model: characterization and neural control of exocrine release", Autonomic Neuroscience: Basic and Clinical, Volume 105, Issue 2, Pages 118-130; 30 May 2003, Connie A Meachama, Adriel D Johnson Sr.

"The involvement of slaframine and swainsonine in slobbers syndrome: a review" Journal of Animal Science, Journal of Animal Science, (1995) Vol 73, Issue 5 1499-1508. W. J. Croom Jr, W. M. Hagler Jr, M. A. Froetschel and A. D. Johnson.

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Ursula Goodenough of journal of cell science

Ursula W. Goodenough (born March 16, 1943) is a Professor of Biology Emerita Washington University in St. Louis where she engaged in research on eukaryotic algae. She authored the best-selling book The Sacred Depths of Nature, and has presented the paradigm of Religious Naturalism and the Epic of Evolution in numerous venues around the world. She contributed to the NPR blog, 13.

7: Cosmos & Culture, from 2009 to 2011. She currently serves as president of the Religious Naturalist Association

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Cause of journal of cell science

Normal adult hemoglobin A molecule comprises two and two globin chains associated with a heme ring. Mutation at the 6th position of the beta chain is the cause of sickle cell disease. Due to sickle cell disease, vascular occlusion may occur in the conjunctiva, iris, retina, or choroid. Retinal changes occur due to blockage of retinal blood vessels by abnormal RBCs.

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The concept of Interleukin-6 trans-signaling of journal of cell science

The Hyper-IL-6 protein has also been used to explore the physiologic role of Interleukin-6 trans-signaling in vivo. It turned out that this signaling mode was involved in many types of inflammation and cancer.

Hyper-IL-6 has helped to establish the concept of Interleukin-6 trans-signaling. Interleukin-6 trans-signaling mediates the pro-inflammatory activities of Interleukin-6 whereas Interleukin-6 classic signaling governs the protective and regenerative Interleukin-6 activities.

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Education and academic career of journal of cell science

Bertolotti studied for her PhD with Lazlo Tora and Pierre Chambon at the University of Strasbourg in France. She pursued her post doctoral training with David Ron at the Skirball Institute of Biomolecular Medicine, NYU Medical Center, New York, United States. In 2001, Bertolotti became Associate Professor at Ecole Normale Superieure, Paris. In 2006, she became a group leader at the MRC Laboratory of Molecular Biology.

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Honours of journal of cell science

Vidal-Puig gave the 2015 FEBS National Lecture, the 2016 Maimonides Lecture Award by the University of Crdoba, and the 2019 Sir Philip Randle Lecture sponsored by the British Biochemical Society.

He has been awarded the Lilly Foundation Distinguished Career Award (2015) , the Hippocrates International Award for Medical Research on Human Nutrition given by the Real Academia de Medicina y Ciruga of the Principality of Asturias (2015) the Society for Endocrinology Medal (2017).

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Interactions of journal of cell science

Drugs that potentiate or prolong the effects of sulfonylureas and therefore increase the risk of hypoglycemia include acetylsalicylic acid and derivatives, allopurinol, sulfonamides, and fibrates. Drugs that worsen glucose tolerance, contravening the effects of antidiabetics, include corticosteroids, isoniazid, oral contraceptives and other estrogens, sympathomimetics, and thyroid hormones. Sulfonylureas tend to interact with a wide variety of other drugs, but these interactions, as well as their clinical significance, vary from substance to substance.

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Medusavirus of journal of cell science

Medusavirus is a large DNA virus isolated from a Japanese hot spring, among other places worldwide, and is notable for having complete set of histone related genes. The virus can harden defenseless amoebas into stone-like cysts, but usually burst. The possibility that evolutionary emergence of complex eukaryotic cells from simpler prokaryotic cells has been suggested. The virus was named after Medusa, the Greek mythological monster whose gaze turned people to stone.

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Awards and recognition of journal of cell science

"Bharat Gaurav" award for Distinguished Services to the Nation & Outstanding Individual Achievements at the House of Commons of the British Parliament in London, UK.

Coveted Sushrut Award in 2010, at Mumbai by the Red Swastik Society, for commendable or exemplary work in the field of Surgery-cum-Community Service.

Excellence in services in stem cell therapy by Times health excellence award at the hands of India's senior-most & highly respected Oncologist, Dr.Suresh Advani.

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Erika L. Pearce of journal of cell science

Erika L. Pierce is an American immunologist. Since 2015, she has been a Director and a Scientific Member at Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany. Her work investigates the connection between metabolism and immune cell function with a particular focus on the regulation of T-cells. In 2018, she was awarded the Leibniz Prize for her "outstanding work in metabolism and inflammation research".

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J. Herbert Taylor of journal of cell science

James Herbert Taylor (January 14, 1916 in Corsicana, Texas December 29, 1998 in Tallahassee, Florida) was an American molecular biologist and geneticist known for his research on chromosome structure and reproduction, which helped establish standards for the subsequent field of molecular genetics. He conducted much of this research with his wife, Shirley Taylor. According to a 2006 Cold Spring Harbor Laboratory textbook, Taylor comes as close as anyone to being the father of the field of studying chromosomes.

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Education and previous appointments of journal of cell science

Sullenger obtained his B.S. in Biology from Indiana University and his Ph.D. in Molecular Biology from Cornell University and Memorial Sloan-Kettering Cancer Center. He performed postdoctoral studies in Thomas Cechs laboratory in the Department of Biochemistry at the University of Colorado. Since coming to Duke University in 1994, he has held positions in the Departments of Surgery, Molecular Genetics and Microbiology, and Pharmacology and Cancer Biology.

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Breast Cancer Metabolism of journal of cell science

Breast cancer stem cells establish their cell identity by expressing unique pattern of proteins and surface markers as fingerprints. Accordingly, breast cancer stem cells have distinctive metabolic properties to sustain their stemness and promote cancer progression. While reduced ROS Level promotes radioresistance and EMT phenotype of cancer stem cells, Notch signaling interacts with cellular metabolism to promote breast cancer stem cell.

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CIITA of journal of cell science

CIITA is a human gene which encodes a protein called the class II, major histocompatibility complex, transactivator. Mutations in this gene are responsible for the bare lymphocyte syndrome in which the immune system is severely compromised and cannot effectively fight infection. Chromosomal rearrangement of CIITA is involved in the pathogenesis of Hodgkin lymphoma and primary mediastinal B cell lymphoma.

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Career and awards of journal of cell science

University of Aberdeen - BSc, MB, ChB, PhD.

Professor of Pathology and Head of the Department, University of Cambridge, England, and an Honorary Consultant, Addenbrooke's Hospital, Cambridge.

1994 - Bertner Award, MD Anderson Cancer Centre, University of Texas, USA.

1995 - Fellow of the Royal Society.

1998 - Hans Bloemendal Award, University of Nijmegen.

1999 - Gairdner Foundation International Award.

2001 - Scheele Award

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Physics of journal of cell science

August Ada Hitchins' experimental results indicating that radium is formed by the decay of uranium are published.

November 25 Albert Einstein presents to the Prussian Academy of Sciences the Einstein field equations of general relativity. He abandons his hole argument for general relativity.

Arnold Sommerfeld develops a modified Bohr atomic model with elliptic orbits to explain relativistic fine structure.

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Clinical significance of journal of cell science

Gastric lipase can partially compensate for the decrease in production of pancreatic lipase associated with pancreatic dysfunction, giving some means for the body to digest lipids. A limitation of acidic lipases is that they remove only one fatty acid from each triacylglycerol. The free fatty acid can readily cross the epithelial membrane lining the gastrointestinal tract, but the diacylglycerol cannot be transported across. This leaves the acidic lipases less efficient than alkaline lipases

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Evolutionary significance of journal of cell science

In an evolutionary context, neural mechanisms of conspecific song preference in the auditory pathway are important for species recognition. Species recognition traits play a central role in both the origin and maintenance of reproductive isolation. Furthermore, a shared neural mechanism for conspecific song preference has implications for the coevolution of male song and female preference, which may help explain the dramatic diversity of song phenotypes in extant songbirds<.>------

Sic1 of journal of cell science

Sic1, a protein, is a stoichiometric inhibitor of Cdk1-Clb (B-type cyclins) complexes in the budding yeast Saccharomyces cerevisiae. Because B-type cyclin-Cdk1 complexes are the drivers of S-phase initiation, Sic1 prevents premature S-phase entry. Multisite phosphorylation of Sic1 is thought to time Sic1 ubiquitination and destruction, and by extension, the timing of S-phase entry.

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Selected works of journal of cell science

Cell-Free Transmission in Adult Swiss Mice of a Disease Having the Character of a Leukemia. Journal of Experimental Medicine 105 (1957): 307318

The Coming of Age of Tumor Virology. Cancer Research 37 (1977): 12551263

Hemoglobin Synthesis in Murine Virus-induced Leukemic Cells in Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide, with W. Scher, J.G. Holland, and T. Sato. Proceedings of the National Academy of Sciences 68 (1971): 378382.

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Donor robbery of journal of cell science

Funds for research in developing countries are often provided by bilateral and international academic and research programmes for sustainable development. Through donor robbery a large proportion of such international funds may end up in the wealthier countries via consultancy fees, laboratory costs in rich universities, overhead or purchase of expensive equipment, hiring expatriates and running enclave research institutes, depending on international conglomerates such as CGIAR.

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Applications of journal of cell science

Since 1998, the MS2 operator hairpin and coat protein have found utility in the detection of RNA in living cells (see MS2 tagging). MS2 and other viral capsids are also currently under investigation as agents in drug delivery, tumor imaging, and light harvesting applications.

MS2, due to its structural similarities to noroviruses, its similar optimum proliferation conditions, and non-pathogenicity to humans, has been used as substitute for noroviruses in studies of disease transmission.

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Investigations of journal of cell science

In 2013, trials of Dz13 were suspended after concerns were raised about alleged duplicated images in a 2010 paper. A series of investigations conducted by independent expert panels of inquiry under the Australian Code for the Responsible Conduct of Research found genuine error and made no finding of misconduct. This decision was discussed in a news article by the Australian Broadcasting Corporation in October 2019.

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Research of journal of cell science

Huttenhower joined the Harvard T.H. Chan School of Public Health in 2009 as an assistant professor of computational biology and bioinformatics, becoming an associate professor in 2013. Huttenhower's lab worked extensively with the NIH Human Microbiome Project (HMP) to identify and characterise the microorganisms found in association with both healthy and diseased humans. As of 2015, he co-leads one of the follow-up 'HMP2' Centers for Characterizing the Gut Microbial Ecosystem in Inflammatory Bowel Disease.

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